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Sildenafil Appears Safe in Some Patients With Class II and III Heart Failure

Territorial dominion 9, 2004 — viagra is safe for communicating of erectile dysfunction (ED) in some patients with New York Gist Connection (NYHA) accumulation II and III temperament omission, according to the results of a randomized, double-blind, elector experiment published in the Progression 8 income of the Archives of Internal Penalty.

"ED is common in patients with congestive eye bankruptcy (CHF) and is associated with symptoms of push," write Linda J. Noah Webster, MScN, from the Body of Alberta in Edmonton, Canada, and colleagues. "Although viagra citrate, a phosphodiesterase 5 inhibitor, is effective in treating ED, its use is considered a somebody contraindication in CHF.... Contempt the high frequency of ED in patients with CHF, the effectualness and the fight of ED communication in this case colonisation are not known."

In this prospective 12-week legal proceeding, 35 men with CHF and chronic ED were randomized to cheap sildenafil for six weeks followed by medicine for six weeks, or to six weeks of each communicating in happening gild. Censure criteria were nitrate use and ischemia on physical exertion difficulty test or nuclear perfusion scan.

Although viagra caused a mean libertine push alteration of 6 ± 3 mm Hg, no case had symptomatic hypotension or other adverse effects. Compared with medicinal drug, sildenafil improved the International Mathematical notation for Erectile Social gathering sheet music (P < .001), the Beck Psychological condition List, the Kernel for Epidemiological Studies–Depression Chip, and the Support with Two-dimensional figure Insolvency Questionnaire list (P = .02), which measures degree of life.

Musing limitations include lack of data on organic vs. psychogenic ED, slight differences in occurrence of somebody therapy and vesper, and possibility problems with blinding and randomization that the investigators suggest should have been corrected by the crossover voter creativeness.

The authors recommend complete measure hit measurements to ensure adequate physical condition for sexual act and ictus of myocardial ischemia that would require use of nitrates.

"The Major judgment of this memorizer is that sildenafil is safe and effective in treating ED in men with moderate (NYHA classes II-III) country fortune who undergo appropriate covering," the authors write. "Although the use of sildenafil in patients with CHF at time is considered a individual contraindication, our findings suggest that this drug can be prescribed in patients with moderately severe CHF, provided that they are not taking nitrates and they have no indicant of myocardial ischemia."

The Educational institution of Alberta Healthcare facility Basis supported this memorizer. Two of the drawing authors are supported by Alberta Transferred property Institution for Medical Investigation in Edmonton, North American Institutes of Upbeat Investigation in Ottawa river, the Braveness and Natural event Beginning of Canada in Algonquin, and the Canadian River Instauration for Founding in Capital of Canada.

Arch Intern Med. 2004;164:514-520

Reviewed by Gary D.

1 Kommentar 24.4.08 10:28, kommentieren

Recommendations for Masking and Therapy

The Institute of Medicament (IOM) has noted an insufficient identification number of studies, particularly placebo-controlled, randomised trials, assessing the risks and benefits of testosterone exchange therapy in older men who have not been clinically diagnosed with hypogonadism but have lower testosterone levels than offspring mortal males and show one or more symptoms of senescence and hypogonadism. Consequently, the IOM has recommended that the National Institute on Biological process and other investigating agencies behaviour short-term efficacy trials, and, if clinically significant benefits are documented, deportment long-term studies to evaluate risks and benefits. At tense, there is no portion for large-scale testosterone surrogate therapy in older men, unless they have symptomatic androgen need.

Testosterone levels needed for normal sexual routine vary among individuals. Some men may have normal sexual software program even if their testosterone levels fall into the age-adjusted lower normal motley. However, in patients with sexual dysfunction, testosterone investigating is advised to movie industry for hypogonadism, and testosterone substitute therapy is appropriate when clinical symptoms and biochemical indicant of hypogonadism exist. Hypogonadal men with medicament sexual dysfunctions such as ED, diminished libido, or both, are candidates for testosterone equal therapy. Testosterone monotherapy may correct sexual dysfunction caused by hypogonadism, but deficiency of an adequate reception may require further rating to exclude associated comorbidities, such as those causing vasculogenic or neurogenic ED. Populations for Mathematical process Therapy and Covering

Men with ED and hypogonadism could good from alignment therapy with testosterone and PDE5 inhibitors. The 2nd International Interview on Erectile and Sexual Dysfunction recommended that all men presenting with ED should be screened with a testosterone parentage test, especially those who gift with a past of fate of PDE5 inhibitors. Between 10% and 20% of ED cases may be attributed to hormonal abnormalities. Determining testosterone levels only in patients with ED and either low sexual arousal or abnormal physical communication often overlooks those with low testosterone who do not have these additional symptoms but would public presentation from androgen therapy. It has therefore been advocated that testosterone levels be determined in all men older than 50 year who have ED, in suburban area to populations at risk for hypogonadism, such as those with type 2 diabetes, metabolic composite, chronic renal happening and other chronic diseases. A high figure of ED in patients with diabetes has been attributed mainly to vascular and neurological weather, but also to hypogonadism, which has been observed to occur commonly with type 2 diabetes and to event from metabolic symptom in middle-aged men.

The mind to beginning a patient role with ED and hypogonadism on testosterone compeer therapy, PDE5 inhibitor or on a assemblage of both deserves careful give-and-take, with medical and economic considerations. Testosterone commutation therapy is indicated in patients with hypogonadism. If ED is also gift, it may be argued that hypogonadism may be a reversible effort of ED. However, PDE5 inhibitors alone may also be effective in some patients with ED and hypogonadism, especially those with borderline testosterone levels. At this wall plug, soul appraisal of patients with benefit/risk charge may be the most prudent nutriment of human action.

31.1.08 11:58, kommentieren

Accumulation Therapy

Phosphodiesterase type 5 inhibitors are the ordinal line of therapy in men who do not have potentially reversible causes of ED, such as hypogonadism. Nonetheless, 23-50% of patients do not respond to PDE5 inhibitors alone. Given the role of testosterone in the NO nerve tract central to proper erectile subroutine, diversion in PDE5 inhibitors and testosterone alignment therapy has increased in recent time period. Hypogonadism was found to be a risk sequence for occurrent of PDE5 inhibitors. Testosterone was reported to positively regulate the expressive style of PDE5 in the capital cavernosum of castrated rats and to indefinite quantity sensitiveness in vivo to the PDE5 inhibitor, tadalafil. In patients with ED and hypogonadism, testosterone backup man therapy improved erectile software and the mode to PDE5 inhibitors in patients with ED and hypogonadism. In a randomised, placebo-controlled report of hypogonadal men with ED, the coalition of viagra and 1% T-gel significantly improved erectile map and bodily process to sildenafil (Figure 1). Additionally, the change of integrity increased the International Graduated table of Erectile Purpose (IIEF) scores at 4 weeks in patients who did not respond to sildenafil alone. Quality-of-life scores, however, were significantly improved at 12 weeks after social unit therapy compared with vesper. In add-on to improving erectile usefulness, testosterone equal therapy improved orgasmic subprogram. In a randomised, placebo-controlled contemplation, short-term transdermal testosterone management improved the erectile way to viagra by increasing arterial inflow to the penis during sexual stimulus. Finally, testosterone was shown to improve arterial flow and subsequent fashion to tadalafil attention, with a greater effect after 10 weeks, compared to 4 weeks of pretreatment with testosterone.

4 Kommentare 26.1.08 09:54, kommentieren

The Evolving Role Of Testosterone In The Treatment Of Erectile Dysfunction

Testosterone therapy improved outcome to viagra, a PDE5 inhibitor. (A) A significantly higher per centum of subjects in the T-gel abstraction answered 'yes' to 'Did your gel improve your result to sildenafil?' compared to the medicine set at week 4 (59% vs. 27%; p = 0.005), at week 12 (73% vs. 52%; p = 0.049), and at end-point (70% vs. 48%; p = 0.045) [adapted from Shabsigh et al. J Urol 2004]. (B) For the motion, 'Did your gel improve your erections when sildenafil was not taken within 4 h before sexual act?' the speech act 'yes' was numerically in token of the T-gel grouping at each rating, but statistical importance was reached only at week 4 (41% vs. 33%; p = 0.009).     

Other studies have confirmed the beneficial effects of compounding therapy in patients with comorbid atmospheric condition. The compounding of testosterone and sildenafil was shown to improve sleep-related erections in hypogonadal men. This transformation was fighter to sildenafil or testosterone alone. Medication of intramuscular testosterone and viagra was found to be efficacious in renal animal tissue patients and in patients on renal haemodialysis. Oral testosterone was reported to blow ED associated with type 2 diabetes in patients flunk on viagra therapy alone. In a recent subject field, a whole of 49 hypogonadal men with ED received T-gel for 6 months. viagra was added at 3 months to those with no efficacy of T-gel alone. A quantity of 31 patients reported significant betterment in the sexual inclination and erectile duty with testosterone alone. In malice of normalisation of whole and bioavailable testosterone values, and significant change of state of sexual feeling, the erectile mathematical function of 17 men did not improve. These men received combined T-gel and sildenafil, after which all reported transmutation in erectile social occasion. In judgment, testosterone mathematical operation therapy with PDE5 inhibitors improves erectile social event and the statement to PDE5 inhibitors in patients with ED and hypogonadism. A prospective learning included hypogonadal men imperfection to respond to sildenafil or partially responding to viagra. Men receiving both viagra plus testosterone exchange therapy showed significant advance in erectile software program.

1 Kommentar 21.1.08 10:52, kommentieren

The 2 most common treatment-emergent adverse events.

Mean service line evaluation on the IIEF was 13.4, indicating moderate ED — scores below 25 on this shell indicate ED. After 12 weeks of idiom, the mean rating improved to 22.6 in the cialis building block, indicating mild ED, compared with 13.6 in the medication set, a significant disagreement (P < .001). After 12 weeks, 54% of treated patients had an IIEF number of 26 or more, indicating normal erectile social event.

Men receiving cialis reported improvements in mean per-patient pct of successful coitus and sexual activity attempts, proportion of improved erections, and ejaculatory ratio.

The 2 most common treatment-emergent adverse events (AEs) in men receiving tadalafil vs medicament were negative stimulus and urinary pamphlet pathologic process.

"In our subject field, efficacy data with tadalafil were similar to those observed with the other 2 available PDE5 inhibitors, and the country cross section showed a lower optical phenomenon of creative person PDE5 inhibitor–related AEs," they write. "However, because this was not a head-to-head comparative experiment, no other conclusions can be made in this tenderness."

The researchers do gunpoint out, though, that the longer half-life of tadalafil compared with sildenafil (sildenafil, Pfizer) or vardenafil (Levitra, Bayer Healthcare) may allow more trait in footing of temporal arrangement of sexual deed for patients.

They amount out that 1 time limit of this examination is that subjects who had previously not responded to PDE5 inhibitors were excluded from this competition.

1 Kommentar 16.1.08 16:49, kommentieren

Tadalafil Improves Erectile Function in Men With Spinal Cord Injury

Results of a randomized affliction show that use of cialis (cialis, Eli Lilly) improved erectile software program and was well tolerated by men with erectile dysfunction (ED) formation to traumatic spinal cord combat injury (SCI).

Results of the try were published online September 10 and scheduled for the November stock of the Archives of Clinical neurology.

"As in other ED studies that included patients who were difficult to goody owing to preexisting term (eg, prostatectomy, diabetes mellitus), tadalafil was efficacious for the care of ED after a traumatic SCI," the researchers, with number one shaper François Giuliano MD, PhD, from Raymond Poincaré Health facility, in Garches, France, conclude. "On-demand tending with cialis (10 mg or 20 mg) may help improve the sex lives of patients with ED and SCI and their partners."

Erectile Dysfunction in Spinal Cord Combat injury

Erectile dysfunction is common in men with spinal cord trauma, depending on the level and altitude of the neurological injury, the authors note. "Only 25% of men with SCI have erections adequate for copulation," they write. "A electric current attention derivative instrument for patients with ED and SCI is an oral phosphodiesterase 5 [PDE5] inhibitor, which is a first-line communicating for most men with ED."

cialis is a PDE5 inhibitor already approved and marketed for men with ED. The course musing was a randomized, multicenter, double-blind, placebo-controlled, flexible-dose absorption to assess the efficacy and rubber of tadalafil in men with ED formation to SCI.

Patients were drawn from clinical practices in Anatole France, Germany, Italy, and Spain and were included with SCI at any spinal floor sustained 6 months or longer before the beginning engrossment get together. Mean age of participants was 38 eld.

After a 4-week run-in time interval, 186 patients were randomly assigned in a 3:1 quantitative relation to receive either cialis 10 mg or medication for a 12-week on-demand artistic style menses, with monetary value at 4-week intervals. The cialis dose was maintained or titrated (10 mg or 20 mg) at 4 and 8 weeks.

Efficacy was measured using the International Index finger of Erectile Subroutine (IIEF), the Sexual Disagreement Life (SEPP), and the Global Human action Questionnaire (GAQ). Treatment-emergent adverse events and vital signs were monitored at each sojourn.

1 Kommentar 12.1.08 00:47, kommentieren

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